Evaluation of the Effect of Hydrophilic Polymer Blend to Extend the Release of Clarithromycin from Prepared Microcapsules

Whether the control of oral absorption is desired or the delivery of genes to the interior of specific cellsis sought the drug delivery macromolecule has emerged the most ubiquitous entity. In the current volume, macromolecules and their “younger (and sometimes smaller) cousins,” dendrimers, are presented as components extraordinaire of a variety of drug delivery systems. The therapeutic effect of drugs that have a short biological half-life may be enhanced by formulating them as extendedor sustained-release dosage forms. Extendedand sustained-release dosage forms prolong the time that systemic drug levels are within the therapeutic range and, thus, reduce the number of doses the patient must take to maintain a therapeutic effect, thereby increasing compliance.Here in y research work the different polymer blend of sodium alginate ,methyl cellulose and hydroxypropyl methylcellulose has been used for preparation of the clarithromycin microcapsules.